Carboplatin

Carboplatin is a drug used in chemotherapy. It is one of a group of related drugs called platins, which have a central platinum atom surrounded by four or six ligands. Carboplatin was invented to be a less toxic alternative to cisplatin.[1]

Structure

Like all platins, carboplatin is a platinum coordination complex. Instead of the two chloride ions that are ligands in cisplatin, carboplatin has one 1,1-cyclobutane dicarboxylate (CBDCA) ligand connected to the atom at two different places. This ligand is harder to separate from the platinum atom than the chlorine atoms in cisplatin.[2]

Preparation

Carboplatin can be made from cisplatin or its chemical precursor, cis-diamminodiiodoplatinum, and a salt of 1,1-cyclobutane dicarboxylate.

References

  1. ↑ Lebwohl, D.; Canetta, R. (1998). "Clinical development of platinum complexes in cancer therapy: An historical perspective and an update". European Journal of Cancer. 34 (10): 1522–1534. doi:10.1016/S0959-8049(98)00224-X. PMID 9893623.
  2. ↑ Ciancetta, Antonella; Coletti, Cecilia; Marrone, Alessandro; Re, Nazzareno (2011). "Activation of carboplatin by chloride ions: A theoretical investigation". Theoretical Chemistry Accounts. 129 (6): 757–769. doi:10.1007/s00214-011-0933-9.


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